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Open Access Short report

Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats

Eirini Kanata12, Cynthia Humphreys-Panagiotidis2, Nektarios D Giadinis3, Nikolaos Papaioannou4, Minas Arsenakis1 and Theodoros Sklaviadis2*

Author Affiliations

1 Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece

2 Department of Pharmaceutical Sciences, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

3 Faculty of Veterinary Medicine, Farm Animal Clinic, Aristotle University of Thessaloniki, Thessaloniki, Greece

4 Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Veterinary Research 2014, 45:43  doi:10.1186/1297-9716-45-43

Published: 9 April 2014

Abstract

The present study investigates the potential use of the scrapie-protective Q211 S146 and K222 caprine PRNP alleles as targets for selective breeding in Greek goats. Genotyping data from a high number of healthy goats with special emphasis on bucks, revealed high frequencies of these alleles, while the estimated probabilities of disease occurrence in animals carrying these alleles were low, suggesting that they can be used for selection. Greek goats represent one of the largest populations in Europe. Thus, the considerations presented here are an example of the expected effect of such a scheme on scrapie occurrence and on stakeholders.