Open Access Short report

Mannose receptor may be involved in small ruminant lentivirus pathogenesis

Helena Crespo1, Paula Jauregui1, Idoia Glaria1, Leticia Sanjosé1, Laura Polledo2, Juan F García-Marín2, Lluís Luján3, Damián de Andrés14, Beatriz Amorena1 and Ramsés Reina1*

Author Affiliations

1 Institute of Agrobiotechnology, CSIC-UPNA-Government of Navarra, Ctra Mutilva, Mutilva Baja, 31192, Spain

2 Veterinary Faculty, University of León, León, 24071, Spain

3 Department of Animal Pathology, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

4 Present address: Chair of Hunting and Fishing Resources, University of Córdoba, Ctra Nacional IV-a Km 396, Córdoba, 14071, Spain

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Veterinary Research 2012, 43:43  doi:10.1186/1297-9716-43-43

Published: 16 May 2012

Abstract

Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.