Schematic biosynthesis of the HBGA ABH and Lewis. Several transferase enzymes (boxed) are involved in the addition of relevant monosaccharides (in bold) to synthesise the ABH and Lewis ligands in a variety of tissues. Gal, Galactose; Glc, Glucose; GalNAc, N-Acetylgalactosamine; GlcNAc, N-Acetylglucosamine; Fuc, Fucose. With kind permission from Springer Science + Business Media: Glycoconjugate journal, Norwalk virus-like particles bind specifically to A, H and difucosylated Lewis but not to B histo-blood group active glycosphingolipids, 26(9), 2009, 1172, Nilsson J, Rydell GE, Le Pendu J, Larson G, Figure 1 (the figure includes minor alterations).
Abrantes et al. Veterinary Research 2012 43:12 doi:10.1186/1297-9716-43-12