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Open Access Highly Accessed Review

Virulence of newcastle disease virus: what is known so far?

Jos CFM Dortmans12*, Guus Koch1, Peter JM Rottier2 and Ben PH Peeters1

Author Affiliations

1 Central Veterinary Institute of Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands

2 Virology Division, Department of Infectious Diseases & Immunology, Utrecht University, Faculty of Veterinary Medicine, PO Box 80.163, 3508 TD Utrecht, The Netherlands

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Veterinary Research 2011, 42:122  doi:10.1186/1297-9716-42-122

Published: 23 December 2011

Abstract

In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors.